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KMID : 1123920100240040624
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 4 p.624 ~ p.629
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Cytoprotective and Anti-inflammatory Effects of Nardostachys jatamansi Water Extract Via Expression of HO-1
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Park Cheol
Zheng Min
Seo Eun-A
Kwon Kang-Beom
Ryu Do-Gon
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Abstract
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Nardostachys jatamansi water extract (NJ) has long been used for the treatment of inflammation-and immune-mediated disorders in the oriental countries. However, its site of action and pharmacological mechanism are not fully investigated. In this study, the authors tried to explore the cytoprotective and anti-inflammatory actions of NJ. First of all, NJ has no harmful effects on viability of neuronal cell line HT22 cells in the dose range of 300 mg/ml. On the contrary, it shows cytoprotective effects on the cells treated with reactive oxygen species H2O2. Probably the cytoprotective effects of NJ might be caused by its ability to induce well known cytoprotective gene hem oxygenase-1 (HO-1). Furthermore, NJ shows inhibitory effects on the expression of inducible nitric oxide synthase (iNOS) and NO production which are known to destroy the integrity of both cells and tissues. It also inhibits potent proinflammatory cytokine tumor necrosis factor-alpha (TNF-a) production. The blocking effects of NJ on cytopathic and proinflammatory actions of LPS might be caused by the induction of cytoprotective and anti-inflammatory genes HO-1 in macrophages cell line RAW 264.7 cells. The results in this study suggest NJ could be used for the amelioration of inflammation which is underlying mechanism responsible for most chronic diseases.
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KEYWORD
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Nardostachys jatamansi water extract (NJ) HT22 cells, hem oxygenase-1 (HO-1), tumor necrosis factor-alpha (TNF-a), RAW 264.7 cells
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